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KMID : 1146920220520030293
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Journal of Pharmaceutical Investigation
2022 Volume.52 No. 3 p.293 ~ p.317
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Three-Dimensional Printing for Oral Pharmaceutical Dosage Forms
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Kim Ji-Hoon
Kim Kyeong-Jin
Jin Hyo-Eon
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Abstract
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Background: The advent of three-dimensional (3D) printers in the pharmaceutical industry is making a leap forward. 3D printing technology can be applied to patient-friendly drug development by adjusting drug dose, shape, flavor, and dug release pattern to meet individual patient needs. Oral pharmaceutical dosage forms can be printed using various 3D printing technologies, and it is necessary to understand the characteristics and applied conditions of each printing technology.
Area covered: This article covers five commonly used 3D printing technologies (binder jetting, material extrusion, vat photopolymerization, material jetting, and powder bed fusion) and the properties of four oral pharmaceutical dosage forms (immediate-release tablets, modified-release tablets, orodispersible tablets, and orodispersible films) produced using 3D printing technology.
Expert opinion: 3D printing technologies are suitable for preparing drugs in oral dosage forms. Based on the understanding of the factors of 3D printing that influence drug release, it is possible to develop patient-friendly 3D-printed drugs for various active pharmaceutical ingredients (APIs).
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KEYWORD
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Three-dimensional printing technology, Oral dosage form, Immediate-release tablet, Modified-release tablet, Orodispersible tablet, Orodispersible film
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